Nitration of p190RhoGAP secondary to caveolae‐mediated endocytosis increases endothelial junctional permeability
نویسندگان
چکیده
منابع مشابه
Caveolin-1–eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability
Endothelial barrier function is regulated by adherens junctions (AJs) and caveolae-mediated transcellular pathways. The opening of AJs that is observed in caveolin-1(-/-) (Cav-1(-/-)) endothelium suggests that Cav-1 is necessary for AJ assembly or maintenance. Here, using endothelial cells isolated from Cav-1(-/-) mice, we show that Cav-1 deficiency induced the activation of endothelial nitric ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.121.8